Drug in solid form introduced into a body cavity and dissolved by body temperature?

Drug in solid form introduced into a body cavity and dissolved by body temperature?

• A. Enteric-coated
• B. Gtt.
• C. Lozenge
• D. Suppository

Answer: (D)

A solid dosage form that is inserted into a body cavity and is designed to melt or dissolve at body temperature is a suppository. When placed in the rectum or vagina, the warmth of the body causes the base (often cocoa butter) to soften or melt, releasing the drug for local or systemic effect. This route is especially useful when oral administration isn’t possible or when local action in the anorectal area is desired, and it can bypass some first-pass metabolism. Enteric-coated products are oral tablets or capsules with a protective coating that resists stomach acid and dissolves later in the small intestine, so they aren’t meant to be inserted into a body cavity. Gtt. refers to liquid drops, not a solid. A lozenge is a solid that dissolves in the mouth, not inside a body cavity.

A solid dosage form that is inserted into a body cavity and is designed to melt or dissolve at body temperature is a suppository. When placed in the rectum or vagina, the warmth of the body causes the base (often cocoa butter) to soften or melt, releasing the drug for local or systemic effect. This route is especially useful when oral administration isn’t possible or when local action in the anorectal area is desired, and it can bypass some first-pass metabolism.

Enteric-coated products are oral tablets or capsules with a protective coating that resists stomach acid and dissolves later in the small intestine, so they aren’t meant to be inserted into a body cavity. Gtt. refers to liquid drops, not a solid. A lozenge is a solid that dissolves in the mouth, not inside a body cavity.